Knights Templar
on August 4, 2026 2 views
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0:00 - Introduction
0:28 - Cholesterol and Heart Disease
5:00 - Professor X will see you now…
7:58 - The Terrifying
References
[1] Vafai SB, Täubel J, Ashdown T, et al. In vivo base editing of PCSK9 with VERVE-102 for hypercholesterolemia. N Engl J Med. Published online May 25, 2026. doi:10.1056/NEJMoa2601283.
[2] Rohde E, Lee RG, Mazzola AM, et al. Nonclinical data demonstrate potent and precise inactivation of liver PCSK9 in vivo with clinical stage GalNAc base editing medicine, VERVE-102. Presented at: 93rd European Atherosclerosis Society Congress; May 4-7, 2025; Glasgow, UK.
[3] Ibanez B, Fernández-Ortiz A, Fernández-Friera L, et al. Progression of early subclinical atherosclerosis (PESA) study: JACC focus seminar 7/8. J Am Coll Cardiol. 2021;78(2):156-179. doi:10.1016/j.jacc.2021.05.011.
[4] Ference BA, Yoo W, Alesh I, et al. Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis. J Am Coll Cardiol. 2012;60(25):2631-2639. doi:10.1016/j.jacc.2012.09.017.
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