De-Muzzle America

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Sarah Geoffroy

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Wall Comment

PJ Y?havahu ben-Amos Oh

September 11, 2020 10:24 am

[This article shows that vaccines are totally unnecessary, as we develop memory T-cells in response to exposure to the virus even when we are asymptomatic or have mild symptoms. This refutes much of ... View More[This article shows that vaccines are totally unnecessary, as we develop memory T-cells in response to exposure to the virus even when we are asymptomatic or have mild symptoms. This refutes much of the media's claims that the antibodies wear off within a month. The most obvious reason they would be claiming this is to conceal the fact that lasting immunity depends on the memory T-cells rather than the antibodies.] " Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19 � Takuya Sekine � � Andr� Perez-Potti � � Olga Rivera-Ballesteros � � Soo Aleman � � Marcus Buggert � � Karolinska COVID-19 Study Group � � Open AccessPublished:August 14, 2020 https://www.cell.com/cell/fulltext/S0092-8674(20)31008-4?rss=yes Highlights � 1. Acute phase SARS-CoV-2-specific T cells display an activated cytotoxic phenotype � � 2. Broad and polyfunctional SARS-CoV-2-specific T cell responses in convalescent phase � � 3. Detection of SARS-CoV-2-specific T cell responses also in seronegative individuals � SUMMARY "SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. We here systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits robust, broad and highly functional memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19. "

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Members

Sarah Geoffroy

Adriana Farina

AE Lagoa

Amanda Toft