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Nate LF

Male. Born on September 28, 1988.

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I'm just a pro-life minarchist monetarist incrementalist hated by all. I do not belong to the Party ... View More

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Nate LF

October 29, 2022 11:50 pm

Alkaline Phosphatase Is a Biomarker of Aging LIfespan Extension Advocacy Foundation; October 28th, 2022; ... View MoreAlkaline Phosphatase Is a Biomarker of Aging LIfespan Extension Advocacy Foundation; October 28th, 2022; As serum ALP levels rise, so does the relative risk of death, according to two systematic reviews of relevant studies (meta-analyses). In the first review, four studies that included nine million adults found that ALP values greater than 48 IU/L were associated with significantly increased all-cause mortality. The data did not show a clear relationship between age and ALP in men; however, it did show a clear relationship between age and ALP for women Age-related increases in gut permeability drive inflammation. This further damages the gut and liver while promoting systemic inflammation. Dietary changes that reduce gut permeability and improve gut immune defense are theoretically sound methods of reducing serum ALP. --- Nutritional Helps --- K1 and K2 increase IAP through mechanisms that are not clear [32]. In addition, K2 stimulates osteoblast differentiation and bone ALP [33]. In this context, the increase in ALP is not associated with pathology. Further, recent discoveries suggest that vitamin K2 prevents arterial calcification (hardening of the arteries) and plays an essential role in the trafficking of calcium into bone matrix [33]. Excessive calcium supplementation, especially in older individuals, accelerates arterial calcification [34,35]. Therefore, anyone considering supplementary calcium to optimize ALP would be wise to also consult a physician about Vitamin K2 supplements. Vitamin D3, the bioactive form of vitamin D, regulates the expression of IAP and deficiencies of Vitamin D3 result in inadequate production of IAP. D3 is also necessary to absorb calcium from the gut, which is necessary to maintain bone density. Maintaining adequate intestinal ALP can, paradoxically, keep age-related increases in serum ALP in check by protecting the liver from enterotoxins that would drive up liver ALP. Metformin and berberine inhibit the normal increase in lipopolysaccharide (LPS) that occurs in serum after a high-fat meal. A decrease in LPS suggests that either the composition of gut microbiota has changed or that the intestinal barrier has been modified in a way that blocks normal access by LPS into the bloodstream [36]. This reduces the need to maintain high IAP levels. --- Nutritional Harms that create Dysfunctional ALP Levels --- High-protein diets, in murine models, have been shown to alter the gut microbiome, damage kidneys, and increase intestinal permeability and systemic inflammation [46]. To date, this has not been demonstrated in human beings, and the high-protein diet used in this study contained 52% protein. While there is no unequivocal definition of a high-protein diet, many dieticians define it as when at least 35% of daily calories come from protein Further studies show that mice without the IAP gene develop fatty liver, high triglycerides, and other symptoms of metabolic syndrome when fed a high-fat diet. Studies suggest that while omega-3 fatty acids reduce colonic inflammation, this occurs at the expense of disabling IAP from dephosphorylation LPS [29]. Consequently, mortality was increased among test animals used in this study. those who restricted calorie intake by 25% and lost 10% of their body weight and those who followed a liquid diet and lost 15% of their body weight. Alkaline phosphatase decreased by 9% and 10%, respectively. https://www.lifespan.io/topic/alkaline-phosphatase-is-a-biomarker-of-aging/ #longevity #nutrition #liver #alp #vitamins #minerals #diet

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Alkaline Phosphatase Is a Biomarker of Aging | Lifespan.io

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Phosphatases remove phosphate groups from proteins, changing how they relate to other proteins and providing a crucial function in cellular signaling.

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