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INTERESTING:HOW MANY AMERICANS DIED OF FENTANYL OVERDOSE?According to provisional data from the Centers for Disease Control and Prevention (CDC), an estimated 44,564 people died from opioid-involved overdoses in the United States in 2025, down from 55,296 in 2024. While the vast majority of these synthetic opioid deaths are driven by illicit fentanyl, final specific disaggregated totals dedicated strictly to fentanyl alone for the full calendar year 2025 remain provisional and subject to adjustment.Overall context on 2025 overdose numbers:Total estimated drug overdose deaths fell to roughly 69,973 in 2025.This marked a nearly 14% decline compared to the estimated 81,313 deaths in 2024.The decrease represents the third consecutive annual drop in U.S. overdose mortality.For official reports and ongoing updates, consult the CDC National Center for Health Statistics via the CDC Provisional Drug Overdose Data.