Robert
on December 2, 2025
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Pfizer has been forced to disclose long-withheld Phase 3 results for its mRNA influenza vaccine (PF-07252220), and the data are deeply troubling, particularly for adults aged 65 and older.
The pivotal trial (NCT05540522) enrolled more than 25,000 participants and reached full completion in May 2024.
For the subsequent fourteen months, Pfizer issued no press release, no investor update, no scientific presentation, and no peer-reviewed publication.
Only on July 25, 2025 did the company quietly post primary outcome data on clinicaltrials.gov without commentary or context, effectively delaying public and professional scrutiny of a product it had previously described as a potential breakthrough in seasonal influenza prevention.
Independent review of the posted results reveals the following:
In participants aged 65 and older:
• All-cause mortality: 49 deaths in the mRNA arm vs 46 in the comparator (licensed inactivated vaccine) arm
• Acute kidney injury: 22 cases vs 9 cases
• Acute respiratory failure: 17 cases vs 6 cases
• Severe systemic adverse reactions: 59% vs 33%
• Severe local reactions: 69% vs 26%
The mRNA vaccine failed to demonstrate superiority over existing licensed vaccines and was associated with numerically higher mortality and markedly worse safety outcomes in the highest-risk age group.
In younger adults (18–64), relative efficacy was modest, but the absolute risk reduction was only 0.32%, meaning approximately 300 individuals would need to be vaccinated to prevent one mild-to-moderate case of influenza-like illness, while exposing many more to significant adverse events.
These findings stand in stark contrast to earlier public statements positioning mRNA technology as the future of annual influenza vaccination.
The prolonged delay in disclosure, followed by silent posting of unfavorable results, raises legitimate questions about transparency and accountability.
🔗 Primary data (publicly available):
https://clinicaltrials.gov/study/NCT05540522
🔗 Article: https://justthenews.com/politics-policy/health/pfizer-buries-data-showing-mrna-flu-vaccine-bombed-trial-elderly-not-much?brid=kuEFsZoATR6D0Q1mgJNE4Q
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