Brent Cole - Author
on November 26, 2025
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🚨 New peer-reviewed analysis raises serious questions about the official reference sequence of the SARS-CoV-2 spike protein, the same sequence that served as the template for global diagnostics, PCR tests, and every major COVID-19 vaccine.
Published November 22, 2025, the 27-page paper argues that the Wuhan-Hu-1 spike is not a naturally evolved viral protein but a mosaic containing at least 32 percent human-derived sequence segments.
These segments, the authors claim, align with interchangeable “modules” described in a 2018 U.S. patent (US9884895B2) and mirror techniques developed in U.S.-funded gain-of-function research between 2005 and 2020, including work led by Ralph Baric at UNC-Chapel Hill.
Key findings include:
• Precise matches to patented N-terminal domain (NTD), receptor-binding domain (RBD), and S2 fusion regions designed for plug-and-play assembly
• Insertion of a furin cleavage site using methods documented in multiple pre-2020 publications
• Evidence that the original metagenomic assembly by Chinese researchers in January 2020 may have incorporated unfiltered human reads, potentially creating an artificial consensus sequence
The authors stop short of declaring definitive lab origin but state that the spike protein used worldwide since early 2020 “bears the structural and sequential hallmarks of synthetic construction” rather than zoonotic spillover.
The analysis has already sparked intense debate among virologists and biosecurity experts.
đź”— Read the full paper: https://jonfleetwood.substack.com/p/new-analysis-shows-wuhan-spike-protein
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