Simulation of millisecond protein folding: NTL9 (from Folding@home)

Simulating protein folding on the millisecond timescale has been a major challenge for many years. In a recent paper (http://pubs.acs.org/doi/abs/10.1021/ja9090353), Folding@home researchers Vincent Voelz, Greg Bowman, Kyle Beauchamp, and Vijay Pande have broken this barrier. This is a movie of one of the trajectories that folded (i.e. started unfolded and ended up in the folded state). From simulations like these, we have found some new surprises in how proteins fold. Please see the paper (url above) for more details.