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Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination?"Antibody dependent enhancement (ADE) of infection is a safety concern for vaccine strategies.""We show that enhancing antibodies reinforce the binding of the spike trimer to the host cell membrane by clamping the NTD to lipid raft microdomains. This stabilizing mechanism may facilitate the conformational change that induces the demasking of the receptor binding domain." "...neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity. Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors)."SOURCE: J Infect. 2021 Aug 9;S0163-4453(21)00392-3.doi: 10.1016/j.jinf.2021.08.010. Online ahead of print.PMID: 34384810 PMCID: PMC8351274https://pubmed.ncbi.nlm.nih.gov/34384810/